LNP Encapsulation Service

Binhui Biopharma has launched lipid nanoparticles (LNPs) encapsulation services, which can be used for encapsulation of mRNA, circular RNA, siRNA, and DNA.

mRNA is easily degraded by direct injection into the body, and can be encapsulated using LNP. Ionizable cationic lipids in LNP can bind well with mRNA and then self assemble with other auxiliary lipid components to form lipid nanoparticles (LNPs). LNP can effectively fuse with the cell membrane, allowing the encapsulated mRNA to enter the cell and exert its effects.

At the same time, Binhui Biopharma provides encapsulation instruments and supply of ionizable cationic lipid raw materials to meet the needs of customers for nucleic acid based drug and vaccine research and production.

Packaging Diagram

Provide customized services for customers, including small interfering RNA (siRNA), microRNA (miRNA), small activating RNA (saRNA), messenger RNA (mRNA), circular RNA, DNA, and other small and medium-sized package packaging.

Service Advantages

1、Self developed liposomes (Lipid series) and commercial liposomes (SM102, MC3) can be customized

2、Comprehensive quality control and quality system (producedmanufactured according to GMP level requirements)

3、Professional team with specilized facilities and equipment (includes self-developed pilot and med-scale encapsulation equipment).

4、Capable of  encapsulate various types of RNA/DNA (mRNA, circular RNA, siRNA, DNA)

5、High efficiency of in vitro transfection

6、Efficiently stimulates antibody production in vivo

Service details

Support customer customization and flexible preparation based on customer selection

Quality control standards

Customized liposome encapsulation service

Note: Specific inspection items can be customized according to customer needs, with "√" indicating recommended inspection items and "O" indicating optional options.

Example

1、Encapsulation particle size diagram and electron microscopy image

2、Distribution effect diagram of different liposomes

3、EGFP in vitro transfection map

4、Fluc in vivo fluorescence expression map

5、Antibody titer map